反応 #5008

ord-72cd4b260c0043e8aa2503a92dce1f5e

反応方程式

COC(=O)c1cccc(C)c1
Methyl m-toluate
O=C1CCC(=O)N1Br
NBS
CC(C)(C#N)N=NC(C)(C)C#N
AIBN
→
COC(=O)c1cccc(CBr)c1
methyl m-bromomethylbenzoate

反応物

COC(=O)c1cccc(C)c1
Methyl m-toluate
O=C1CCC(=O)N1Br
NBS
CC(C)(C#N)N=NC(C)(C)C#N
AIBN

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

Methyl m-toluate was brominated with NBS and AIBN as described in Example 21 to give methyl m-bromomethylbenzoate, and this was further reacted with triethyl phosphite as described in Example 2 without further purification.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05242908uspto-grants-1993_09