反応 #5004

反応方程式

methyl 2-acetyl-6-[(4,6-dimethoxytriazin-2-yl)oxy]benzoate

methoxyamine hydrochloride

potassium acetate

methanol

→

aimed compound

収率 48.0%

methyl 2-[(4,6-dimethoxytriazin-2-y1)oxy]-6-[1-(N-methoxyimino)ethyl]benzoate

収率 48.0%

溶媒

water

反応条件

後処理

1. 1
   その他The resultant reaction liquor
2. 2
   抽出was extracted with ethyl acetate
3. 3
   洗浄After washing the extracted product with water
4. 4
   その他the washed product was dried
5. 5
   濃縮concentrated
6. 6
   その他to obtain an oily product
7. 7
   その他This was then purified by column chromatography

実験手順

0.9 of methyl 2-acetyl-6-[(4,6-dimethoxytriazin-2-yl)oxy]benzoate, 0.68 g of methoxyamine hydrochloride and 0.80 g of potassium acetate were added to 30 ml of methanol, and the resultant mixture was stirred for one day and one night at room temperature. The resultant reaction liquor was poured into water, and was extracted with ethyl acetate. After washing the extracted product with water, the washed product was dried and concentrated to obtain an oily product. This was then purified by column chromatography to obtain 0.47 g of the aimed compound (melting point=131° to 135° C.) at a yield of 48%.

出典