反応 #50011

反応方程式

ethyl acetate

Triethylamine

2,4-dichloro-6-fluoro-7-hydrazinobenzothiazole

Pivaloyl chloride

→

2,4-dichloro-6-fluoro-7-[N-(2,2-dimethylpropanoyl)hydrazino]benzothiazole

溶媒

toluene

反応条件

後処理

1. 1
   洗浄washed with aqueous sodium hydrogen carbonate and water
2. 2
   乾燥dried over magnesium sulfate
3. 3
   濃縮concentrated
4. 4
   その他The residue was purified by column chromatography

実験手順

2.6 ml Triethylamine was added to a solution of 4.8 g 2,4-dichloro-6-fluoro-7-hydrazinobenzothiazole in 38 ml toluene. 2.4 ml Pivaloyl chloride was added dropwise and the mixture stirred for 2 hours at room temperature. It was then treated with ethyl acetate and washed with aqueous sodium hydrogen carbonate and water, dried over magnesium sulfate and concentrated. The residue was purified by column chromatography. Yield: 1.36 g=21% of theory

出典