反応 #50001

反応方程式

7-amino-2,4-dichloro-6-fluoro-benzothiazole

3,4,5,6-tetrahydrophthalic anhydride

→

N-(2,4-Dichloro-6-fluorobenzothiazol-7-yl)-3,4,5,6-tetrahydrophthalimide

溶媒

acetic acid

反応条件

後処理

1. 1
   温度under reflux for 5 hours
2. 2
   温度After cooling
3. 3
   その他the resulting crystals were separated off
4. 4
   その他They were dried at 50° C. in vacuo
5. 5
   その他purified by column chromatography

実験手順

A solution of 6 g 7-amino-2,4-dichloro-6-fluoro-benzothiazole and 4.3 g 3,4,5,6-tetrahydrophthalic anhydride in 50 ml acetic acid was heated under reflux for 5 hours. After cooling, the reaction solution was poured into 200 ml ice-water and the resulting crystals were separated off. They were dried at 50° C. in vacuo and then purified by column chromatography. Yield: 6.6 g=70% of theory m.p.: 139°-141° C.

出典