反応 #500003

反応方程式

K3PO4

2-Bromo-m-xylene

2-methylphenylboronic acid

→

title compound

収率 87.0%

2,6dimethyl-2′-methyl-1,1′-biphenyl

収率 87.0%

溶媒

toluene

反応条件

後処理

1. 1
   その他at 100° C.

実験手順

2-Bromo-m-xylene (186 mg, 1.01 mmol) reacted with 2-methylphenylboronic acid (164 mg, 1.21 mmol) using 2/4 mol % of Pd(dba)2/Ph5FcP(t-Bu)2 and K3PO4 (640 mg, 3.00 mmol) in toluene at 100° C. to give the title compound (170 mg, 87%) as a colorless oil: 1H-NMR (400 MHz, CDCl3): δ 7.31-7.25 (m, 3H), 7.20-7.11 (m, 3H), 7.03 (m, 1H), 1.98 (s, 3H), 1.96 (s, 6H).

出典