反応 #4998

反応方程式

2,3-dimethylmaleic anhydride

methyl 4-amino-2-(aminosulfonyl)benzoate

→

methyl 2-(aminosulfonyl)-4-(2,5-dihydro-3,4-dimethyl-2,5-dioxo-1H-pyrrol-1-yl)benzoate

収率 43.0%

溶媒

acetic acid

反応条件

後処理

1. 1
   workup.DISTILLATIONAcetic acid was then distilled off from the reaction mixture
2. 2
   workup.ADDITIONfollowed by the addition of 20 ml of ice water to the oily residue
3. 3
   その他After the mixture thus formed
4. 4
   ろ過the resulting precipitate was collected by filtration
5. 5
   その他dried in air

実験手順

In 3 ml of acetic acid, 1 mmol of methyl 4-amino-2-(aminosulfonyl)benzoate and 1.05 mmol of 2,3-dimethylmaleic anhydride were stirred at 80° C. for 40 hours. Acetic acid was then distilled off from the reaction mixture, followed by the addition of 20 ml of ice water to the oily residue. After the mixture thus formed was stirred for 2 hours, the resulting precipitate was collected by filtration and then dried in air. Yield: 43%. Its physicochemical properties are shown in Table 8.

出典