反応 #49957

反応方程式

1-benzyl-1,4,7,10-tetraazacyclododecane

dimethylformamide diethylacetal

→

final product

収率 96.0%

7-benzyl-octahydro-5H,9bH-2a,4a,7,9a-tetraazacycloocta[cd]pentalene

収率 96.0%

溶媒

benzene

反応条件

後処理

1. 1
   workup.DISTILLATIONand the azeotropic mixture ethanol-benzene is distilled away
2. 2
   その他the solvent is evaporated under reduced pressure

実験手順

A solution of 1-benzyl-1,4,7,10-tetraazacyclododecane (4 g; 0.015 mol) and dimethylformamide diethylacetal (6.88 g; 0.0467 mol) in benzene (40 ml) is heated at 80 C. and the azeotropic mixture ethanol-benzene is distilled away. When the conversion is ended, the solvent is evaporated under reduced pressure and the final product is obtained as a yellow oil (4.0 g). Yield 96%

出典