反応 #49918

反応方程式

sodium hydroxide

t-butylhydrazine hydrochloride

benzoyl chloride

sodium hydroxide

→

N'-t-butyl-N-benzoylhydrazine

溶媒

toluene

toluene

反応条件

後処理

1. 1
   その他from separate
2. 2
   workup.ADDITIONaddition funnels
3. 3
   温度while maintaining the temperature at or below 10° C
4. 4
   workup.ADDITIONthe addition
5. 5
   温度the reaction mixture was warmed to room temperature
6. 6
   workup.ADDITIONThe reaction mixture was diluted with hexane

実験手順

To a stirred suspension of t-butylhydrazine hydrochloride (2 g, 0.016M) in toluene (50 ml) at room temperature was added dropwise a 50% aqueous solution of sodium hydroxide (1.28 g, 0.016M). After 15 minutes, the reaction mixture was cooled to 5° C. and a solution of benzoyl chloride (2.3 g, 0.017M) in toluene (5 ml) and a solution of aqueous 50% sodium hydroxide (1.36 g, 0.017M) were added dropwise simultaneously from separate addition funnels while maintaining the temperature at or below 10° C. Following the addition, the reaction mixture was warmed to room temperature and stirred for 1 hour. The reaction mixture was diluted with hexane and the solid N'-t-butyl-N-benzoylhydrazine was isolated by filtration.

出典