反応 #499001

反応方程式

4,4′-dimethoxytrityl chloride

4-hydroxybutyric acid

Pyridine

→

crude title compound

4-[(4,4′-Dimethoxytrityl)oxy]Butyric Acid, Triethylammonium Salt

反応条件

後処理

1. 1
   濃縮concentrated to an oil in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in a mixture of MeOH and CH2Cl2 (95:5
3. 3
   洗浄200 mL) and washed with 2M aqueous triethylammonium acetate (5×20 mL)
4. 4
   その他The organic solution was evaporated
5. 5
   workup.DISSOLUTIONre-dissolved in CH2Cl2
6. 6
   乾燥dried over Na2SO4
7. 7
   その他evaporated

実験手順

A solution of 4,4′-dimethoxytrityl chloride (695 mg, 2.05 mmol) and 4-hydroxybutyric acid (208 mg, 2.0 mmol) in anhydrous Pyridine (20 mL) was stirred overnight and concentrated to an oil in vacuo. The residue was dissolved in a mixture of MeOH and CH2Cl2 (95:5, v/v; 200 mL) and washed with 2M aqueous triethylammonium acetate (5×20 mL). The organic solution was evaporated, re-dissolved in CH2Cl2, dried over Na2SO4, and evaporated to give the crude title compound in a quantitative yield (1016 mg).

出典