反応 #4985

反応方程式

Iodouridine

N-propargyltrifluoroacetamide

methanol

→

alkynylamino nucleoside

5-(3-trifluoroacetamido-1-propynyl)-2', 3'-dideoxyuridine

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他to dry
2. 2
   その他vacuum-drying

実験手順

Iodouridine 21 was coupled for 3 hours to N-propargyltrifluoroacetamide following the general method given in Example 5C. Chromatography with a 0-5% methanol in dichloromethane gradient afforded material which was homogeneous by TLC, but which was difficult to dry. After co-evaporating the chromatographed product several times with chloroform and vacuum-drying, 536.5 mg of alkynylamino nucleoside 22 was obtained as a white foam. This material was homogeneous by TLC and was pure by NMR except for a small amount (39 mole%; corrected yield 66%) of chloroform.

出典