反応 #498440

反応方程式

pentafluoropyridine

2,2-dimethyl-1,3-dioxolane-4-methanol (solketal)

Cs2CO3

→

2,3,5,6-tetrafluoro-4-[[(2,2-dimethyl)dioxolan-4-yl]methoxy]pyridine

収率 94.8%

溶媒

DMSO

反応条件

後処理

1. 1
   その他The reaction was partitioned with water and ethyl acetate
2. 2
   洗浄washed with water and brine
3. 3
   乾燥dried (Na2SO4)
4. 4
   その他the solvent was removed

実験手順

To pentafluoropyridine (2.0 g, 12 mmol) dissolved in DMSO was added 2,2-dimethyl-1,3-dioxolane-4-methanol (solketal) (1.5 mL, 12 mmol) and Cs2CO3 (3.8 g, 12 mmol). The slurry was heated in an oil bath at 60° C. for 1 day. The reaction was partitioned with water and ethyl acetate, washed with water and brine, dried (Na2SO4) and the solvent was removed to give 2,3,5,6-tetrafluoro-4-[[(2,2-dimethyl)dioxolan-4-yl]methoxy]pyridine (3.2 g).

出典