反応 #49826

反応方程式

N-[1,4-Dihydro-1-phenyl-3-(2-phenylcarbamoyl-cyanoacetyl) -indeno[1,2-c]pyrazol-7-yl]carbonyl-glycine methyl ester

HCl

→

N-[1,4-dihydro-1-phenyl-3-(2-phenylcarbamoyl-cyanoacetyl) -indeno[1,2-c]pyrazol-7-yl]carbonyl glycine

収率 79.5%

溶媒

ethanol

—

ice water

KOH

反応条件

後処理

1. 1
   温度heated
2. 2
   温度After cooling the reaction mixture
3. 3
   ろ過The precipitate is filtered
4. 4
   洗浄washed with water
5. 5
   その他crystallized from CH2Cl2 /ethanol

実験手順

N-[1,4-Dihydro-1-phenyl-3-(2-phenylcarbamoyl-cyanoacetyl) -indeno[1,2-c]pyrazol-7-yl]carbonyl-glycine methyl ester (0.84 g) is suspended in 1% KOH solution in 95% ethanol (22.3 ml) and heated under stirring at the reflux temperature for 30 minutes. After cooling the reaction mixture is acidified to pH 2 with 23% HCl and then diluted with ice water. The precipitate is filtered, washed with water and then crystallized from CH2Cl2 /ethanol to yield 0.65 g of pure N-[1,4-dihydro-1-phenyl-3-(2-phenylcarbamoyl-cyanoacetyl) -indeno[1,2-c]pyrazol-7-yl]carbonyl glycine.

出典