反応 #49803

反応方程式

water

Benzyl alcohol

triethylamine

{o-[5-(2,4-dichlorophenoxy)-2-nitrophenoxy]phenoxy}acetyl chloride

→

title product

収率 77.8%

Benzyl {o-[5-(2,4-dichlorophenoxy)-2-nitrophenoxy]phenoxy}acetate

収率 77.8%

溶媒

tetrahydrofuran

—

hexanes

methylene chloride

反応条件

後処理

1. 1
   抽出extracted with ether
2. 2
   洗浄The combined organic extracts are washed sequentially with one molar hydrochloric acid, water and brine
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   濃縮concentrated in vacuo
5. 5
   その他to obtain an oil

実験手順

Benzyl alcohol (0.8 mL, 7.73 mmol) and triethylamine (1 mL, 7.17 mmol) are added to a mixture of {o-[5-(2,4-dichlorophenoxy)-2-nitrophenoxy]phenoxy}acetyl chloride (1.12 g, 2.38 mmol) in tetrahydrofuran. The reaction mixture is stirred for twenty minutes, poured into water and extracted with ether. The combined organic extracts are washed sequentially with one molar hydrochloric acid, water and brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to obtain an oil. Column chromatography of the oil using silica gel and a hexanes in methylene chloride solution gives the title product as a yellow oil (1.0 g) which is identified by NMR spectral analyses.

出典