反応 #49801

反応方程式

{o-[5-(2,4-dichlorophenoxy)-2nitrophenoxy]phenoxy}acetyl chloride

ammonia

ethanol

N,N-dimethylformamide

→

title product

2-{o-[5-(2,4-Dichlorophenoxy)-2-nitrophenoxy]phenoxy}acetamide

溶媒

water

反応条件

後処理

1. 1
   抽出extracted with an ether/ethyl acetate (1:1) solution
2. 2
   洗浄The combined organic extracts are washed sequentially with water and brine
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   濃縮concentrated in vacuo

実験手順

A mixture of {o-[5-(2,4-dichlorophenoxy)-2nitrophenoxy]phenoxy}acetyl chloride (1.11 g, 2.38 mmol), ammonia solution (5 mL of a 35% solution), ethanol (5 mL) and N,N-dimethylformamide (10 mL) is stirred for one hour, poured into water and extracted with an ether/ethyl acetate (1:1) solution. The combined organic extracts are washed sequentially with water and brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to give the title product as a yellow oil (1.0 g) which is identified by NMR spectral analyses.

出典