反応 #49711

反応方程式

methyl 4-hydroxybenzoate

octadecylbromide

potassium carbonate

→

methyl 4-octadecyloxybenzoate

収率 45.4%

溶媒

2-butanone

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度at reflux for 16 hours
3. 3
   その他The solvent was then removed until 125 ml of 2-butanone
4. 4
   その他had been collected
5. 5
   温度While it was still warm
6. 6
   workup.ADDITIONthe remaining material was poured into methanol (400 ml)
7. 7
   ろ過The product was filtered
8. 8
   その他recrystallized from 2000 ml of methanol

実験手順

A mixture containing methyl 4-hydroxybenzoate (45.6 g), octadecylbromide (100 g), and potassium carbonate (41.4 g) in 2-butanone (200 ml) was heated at reflux for 16 hours. The solvent was then removed until 125 ml of 2-butanone had been collected. While it was still warm, the remaining material was poured into methanol (400 ml). The product was filtered and recrystallized from 2000 ml of methanol to give methyl 4-octadecyloxybenzoate (55 g).

出典