反応 #4968

反応方程式

4-ethoxyphenylacetylene

3,4-difluoroiodobenzene

triethylamine

→

3,4-difluoro-4'-ethoxytolan

溶媒

methyl tert.-butyl ether

反応条件

後処理

1. 1
   ろ過filtered with suction
2. 2
   その他the solution is evaporated
3. 3
   その他Purification
4. 4
   その他by chromatography and/or crystallization

実験手順

0.4 mmol of bis(triphenylphosphine)palladium(II) chloride and 0.2 mmol of CuI are added at room temperature to a mixture of 0.02 m of 4-ethoxyphenylacetylene, 0.02 m of 3,4-difluoroiodobenzene and 50 ml of triethylamine. The reaction mixture is stirred at room temperature for 2 hours, diluted with 100 ml of methyl tert.-butyl ether and filtered with suction, and the solution is evaporated. Purification by chromatography and/or crystallization gives 3,4-difluoro-4'-ethoxytolan, K 67 I, Δε=11.18.

出典