反応 #49673

反応方程式

3-(R,S)-(1-carbamoyl-1,1-diphenylmethyl)piperidine

1-bromo-3-(4-methoxyphenyl)propane

potassium carbonate

→

title compound

3-(R,S)-(1-carbamoyl-1,1-diphenylmetyl)-1-[3-(4-methoxyphenyl)propyl]piperidine

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度under reflux for 16 hours
3. 3
   その他The mixture was partitioned between dichloromethane (30 ml) and 10% aqueous sodium carbonate (30 ml)
4. 4
   その他the layers separated
5. 5
   抽出the aqueous layer extracted with dichloromethane (2×30 ml)
6. 6
   乾燥dried (MgSO4)
7. 7
   濃縮concentrated in vacuo
8. 8
   その他to give a solid which
9. 9
   その他was recrystallised from ethanol

実験手順

A mixture containing 3-(R,S)-(1-carbamoyl-1,1-diphenylmethyl)piperidine (0.26 g), 1-bromo-3-(4-methoxyphenyl)propane (0.23 g), anhydrous potassium carbonate (0.3 g) and acetonitrile (10 ml) was heated under reflux for 16 hours. The mixture was partitioned between dichloromethane (30 ml) and 10% aqueous sodium carbonate (30 ml), the layers separated, and the aqueous layer extracted with dichloromethane (2×30 ml). The dichloromethane extracts were combined, dried (MgSO4) and concentrated in vacuo to give a solid which was recrystallised from ethanol to give the title compound, yield 0.19 g, m.p. 180°-182° C.

出典