反応 #49672

反応方程式

3-(R,S)-(1-cyano-1,1-diphenylmethyl)piperidine

3,4-methylenedioxybenzyl chloride

potassium carbonate

→

title compound

3-(R, S)-(1-cyano-1,1-diphenylmethyl)-1-(3,4-methylenedioxybenzyl)piperidine

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度under reflux for 16 hours
3. 3
   その他The mixture was partitioned between dichloromethane (30 ml) and 10% aqueous sodium carbonate (30 ml)
4. 4
   その他the layers separated
5. 5
   抽出the aqueous layer extracted with dichloromethane (2×30 ml)
6. 6
   乾燥The combined dichloromethane extracts were dried (MgSO4)
7. 7
   濃縮concentrated in vacuo
8. 8
   その他to give a gum which
9. 9
   その他was purified by column chromatography on silica eluting with dichloromethane
10. 10
    workup.ADDITIONcontaining methanol (0% up to 2%)
11. 11
    濃縮concentrated in vacuo

実験手順

A mixture containing 3-(R,S)-(1-cyano-1,1-diphenylmethyl)piperidine (0.27 g), 3,4-methylenedioxybenzyl chloride (0.18 g), anhydrous potassium carbonate (0.3 g) and acetonitrile (10 ml) was heated under reflux for 16 hours. The mixture was partitioned between dichloromethane (30 ml) and 10% aqueous sodium carbonate (30 ml), the layers separated, and the aqueous layer extracted with dichloromethane (2×30 ml). The combined dichloromethane extracts were dried (MgSO4) and concentrated in vacuo to give a gum which was purified by column chromatography on silica eluting with dichloromethane containing methanol (0% up to 2%). The product-containing fractions were combined and concentrated in vacuo to give the title compound as a colourless solid, yield 0.2 g, m.p. 127°-130° C.

出典