反応 #49665

反応方程式

3-(R)-(+)-(1-cyano-1,1-diphenylmethyl)piperidine

4-hydroxymethylphenethyl bromide

potassium carbonate

→

title compound

3-(R)-(+)-(1-cyano-1,1-diphenylmethyl)-1-(4-hydroxymethylphenethyl)piperidine

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度under reflux for 5 hours
3. 3
   その他The mixture was partitioned between dichloromethane (30 ml) and 10% aqueous potassium carbonate (20 ml)
4. 4
   その他the layers separated
5. 5
   抽出the aqueous layer extracted with dichloromethane (2×20 ml)
6. 6
   乾燥The combined dichloromethane extracts were dried (MgSO4)
7. 7
   濃縮concentrated in vacuo
8. 8
   その他to give an oil which
9. 9
   その他was purified by column chromatography on silica eluting with hexane
10. 10
    workup.ADDITIONcontaining dichloromethane (30% up to 70%)
11. 11
    workup.ADDITIONdichloromethane containing methanol (0% up to 5%)
12. 12
    濃縮concentrated in vacuo
13. 13
    その他to give an oil which
14. 14
    その他was crystallised from acetonitrile

実験手順

A mixture containing 3-(R)-(+)-(1-cyano-1,1-diphenylmethyl)piperidine (0.28 g), 4-hydroxymethylphenethyl bromide (0.22 g), anhydrous potassium carbonate (0.28 g) and acetonitrile (10 ml) was heated under reflux for 5 hours. The mixture was partitioned between dichloromethane (30 ml) and 10% aqueous potassium carbonate (20 ml), the layers separated, and the aqueous layer extracted with dichloromethane (2×20 ml). The combined dichloromethane extracts were dried (MgSO4) and concentrated in vacuo to give an oil which was purified by column chromatography on silica eluting with hexane containing dichloromethane (30% up to 70%) then dichloromethane containing methanol (0% up to 5%). The product-containing fractions were combined and concentrated in vacuo to give an oil which was crystallised from acetonitrile to give the title compound as colourless rhombs, yield 0.21 g, m.p. 110°-114° C., {α]D25 +16 2° (c 1.0, CH2Cl2).

出典