反応 #49652
ord-8532a13b49be47c9ad77e4a04bda6575
反応方程式
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1その他prepared by the method of Hanson et al., J
- 2温度to warm to 0°-5° C.
- 3その他The solvent was removed at 0° C. under vacuum
実験手順
Ozone/oxygen was bubbled at -70° C. into a solution of (3S,4S)-N-[(tert-Butyloxy)carbonyl]-4-amino-3-acetoxy-5-phenylpentene (2.55g, 8.0 mmol) [prepared by the method of Hanson et al., J. Ora. Chem., 50, 5399 (1985)] in 100 mL of methylene chloride until a deep blue color persisted. Oxygen was introduced until the blue color completely faded, then 3.0 mL of Me2S was added and the solution was allowed to warm to 0°-5° C. and stand overnight. The solvent was removed at 0° C. under vacuum yielding the title compound as a thick yellow oil which was used without further purification.