反応 #49601

反応方程式

4-Chloro-5-[3-(tert-butoxycarbonylamino)propoxy]-7-iodoisoindolinone

hydrogen chloride methanol

diisopropylether

→

4-chloro-5-(3-aminopropoxy)-7-iodoisoindolinone hydrochloride

収率 193.0%

溶媒

methanol

反応条件

後処理

1. 1
   ろ過The obtained solid was collected by filtration
2. 2
   洗浄washed with diisopropylether
3. 3
   その他by drying under reduced pressure

実験手順

4-Chloro-5-[3-(tert-butoxycarbonylamino)propoxy]-7-iodoisoindolinone (101 mg, 0.216 mmol) was suspended in methanol (1.5 mL), and the suspension was added with 10% hydrogen chloride-methanol solution (1.5 mL), followed by stirring at 60° C. for 1.0 hour. The reaction mixture was added with diisopropylether. The obtained solid was collected by filtration and washed with diisopropylether, followed by drying under reduced pressure to obtain 4-chloro-5-(3-aminopropoxy)-7-iodoisoindolinone hydrochloride (84.0 mg, yield 96%).

出典