反応 #49599

反応方程式

water

potassium carbonate

3-bromopropylcarbamic acid tert-butyl ester

4-chloro-5-hydroxy-7-iodoisoindolinone

→

4-chloro-5-[3-(tert-butoxycarbonylamino)propoxy]-7-iodoisoindolinone

収率 84.0%

溶媒

DMF

反応条件

後処理

1. 1
   ろ過The obtained solid was collected by filtration
2. 2
   その他purified by slurry

実験手順

In a similar manner to Step 1 of Example 429, 4-chloro-5-hydroxy-7-iodoisoindolinone (283 mg, 0.916 mmol) was dissolved in DMF (8.4 mL), and the solution was treated with potassium carbonate (190 mg, 1.37 mmol), tetrabutylammonium iodide (33.8 mg, 0.092 mmol) and 3-bromopropylcarbamic acid tert-butyl ester (654 mg, 2.75 mmol). The reaction mixture was added with water. The obtained solid was collected by filtration and purified by slurry using hexane and diisopropylether to obtain 4-chloro-5-[3-(tert-butoxycarbonylamino)propoxy]-7-iodoisoindolinone (350 mg, yield 84%).

出典