反応 #49598

反応方程式

4-chloro-5-hydroxy-7-iodoisoindolinone

potassium carbonate

tert-butyl(4-iodobutoxy)dimethylsilane

→

4-chloro-5-[4-(tert-butyldimethylsiloxy)butoxy]-7-iodoisoindolinone

収率 84.1%

溶媒

DMF

反応条件

後処理

1. 1
   その他followed by purification by flash column chromatography (chloroform/methanol=99/1, 19/1)

実験手順

In a similar manner to Step 1 of Example 429, 4-chloro-5-hydroxy-7-iodoisoindolinone (70.0 mg, 0.226 mmol) was dissolved in DMF (2.1 mL), and the solution was treated with potassium carbonate (93.8 mg, 0.679 mmol) and tert-butyl(4-iodobutoxy)dimethylsilane (0.176 mL, 0.679 mmol), followed by purification by flash column chromatography (chloroform/methanol=99/1, 19/1) to obtain 4-chloro-5-[4-(tert-butyldimethylsiloxy)butoxy]-7-iodoisoindolinone (94.2 mg, yield 84%).

出典