反応 #49578

反応方程式

water

triethylamine

2-pyridinesulfonyl chloride hydrochloride

4-Hydroxy-5-methoxy-7-iodoisoindolinone

→

4-(2-pyridinesulfonyloxy)-5-methoxy-7-iodoisoindolinone

収率 69.0%

溶媒

acetonitrile

反応条件

後処理

1. 1
   workup.STIRRINGstirred at room temperature for 30 minutes
2. 2
   ろ過The precipitated crystal was collected by filtration

実験手順

4-Hydroxy-5-methoxy-7-iodoisoindolinone (0.465 g, 1.52 mmol) was dissolved in acetonitrile (10.0 mL), and the solution was added with triethylamine (0.850 mL, 6.09 mmol) and 2-pyridinesulfonyl chloride hydrochloride (0.488 g, 2.28 mmol), followed by stirring at room temperature for 5 hours. The reaction mixture was added with water (8.0 mL) and stirred at room temperature for 30 minutes. The precipitated crystal was collected by filtration to obtain 4-(2-pyridinesulfonyloxy)-5-methoxy-7-iodoisoindolinone (0.468 g, yield 69%).

出典