反応 #49574

反応方程式

4-hydroxy-5-methoxy-7-iodoisoindolinone

triethylamine

3-thiophenesulfonyl chloride

→

4-(3-thiophenesulfonyloxy)-5-methoxy-7-iodoisoindolinone

収率 81.0%

溶媒

acetonitrile

反応条件

実験手順

In a similar manner to Step 1 of Example 227, 4-hydroxy-5-methoxy-7-iodoisoindolinone (0.265 g, 0.869 mmol) was dissolved in acetonitrile (8.0 mL), and the solution was treated with triethylamine (0.242 mL, 1.74 mmol) and 3-thiophenesulfonyl chloride (0.191 g, 1.04 mmol) to obtain 4-(3-thiophenesulfonyloxy)-5-methoxy-7-iodoisoindolinone (0.316 g, yield 81%).

出典