反応 #49549

反応方程式

4-methoxymethoxy-5-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

trifluoroacetic acid

triethylsilane

→

4-hydroxy-5-methoxy-7-iodoisoindolinone

収率 71.0%

溶媒

nitromethane

反応条件

後処理

1. 1
   その他followed by purification by slurry

実験手順

In a similar manner to Step 4 of Example 16, 4-methoxymethoxy-5-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (763 mg, 1.58 mmol) was dissolved in nitromethane (12 mL), and the solution was treated with trifluoroacetic acid (1.22 mL, 15.8 mmol) and triethylsilane (2.55 mL, 15.8 mmol), followed by purification by slurry using chloroform to obtain 4-hydroxy-5-methoxy-7-iodoisoindolinone (341 mg, yield 71%).

出典