反応 #49524

反応方程式

trifluoroacetic acid

triethylsilane

4-chloro-5-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

water

→

4-chloro-5-methoxy-7-iodoisoindolinone

収率 64.2%

溶媒

nitromethane

hexane

ethyl acetate

反応条件

後処理

1. 1
   ろ過The precipitated solid was collected by filtration
2. 2
   洗浄washed with hexane and water
3. 3
   その他by drying under reduced pressure

実験手順

In a similar manner to Step 4 of Example 16, 4-chloro-5-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (300 mg, 0.655 mmol) was dissolved in nitromethane (5 mL), and the solution was treated with trifluoroacetic acid (0.505 mL, 6.55 mmol) and triethylsilane (0.212 mL, 1.31 mmol), followed by stirring at room temperature for 24 hours. The reaction mixture was added with water, ethyl acetate and hexane. The precipitated solid was collected by filtration and washed with hexane and water, followed by drying under reduced pressure to obtain 4-chloro-5-methoxy-7-iodoisoindolinone (136 mg, yield 64%).

出典