反応 #49515

反応方程式

3-hydroxy-4,5-dichloro-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

trifluoroacetic acid

triethylsilane

→

4,5-dichloro-7-iodoisoindolinone

収率 74.0%

溶媒

nitromethane

反応条件

後処理

1. 1
   その他followed by purification by slurry

実験手順

In a similar manner to Step 4 of Example 16, 3-hydroxy-4,5-dichloro-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (347 mg, 0.750 mmol) was dissolved in nitromethane (14 mL), and the solution was treated with trifluoroacetic acid (0.867 mL, 11.3 mmol) and triethylsilane (0.240 mL, 1.50 mmol), followed by purification by slurry using chloroform to obtain 4,5-dichloro-7-iodoisoindolinone (182 mg, yield 74%).

出典