反応 #49510

反応方程式

3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone

TMEDA

1,2-dibromotetrachloroethane

→

3-hydroxy-7-bromo-2-(1-methyl-1-phenylethyl)isoindolinone

収率 85.0%

溶媒

THF

反応条件

後処理

1. 1
   その他followed by purification by flash column chromatography (chloroform/methanol=95/5 to 90/10)

実験手順

In a similar manner to Step 3 of Example 16, 3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone (2.00 g, 7.48 mmol) was dissolved in THF (80 mL), and the solution was treated with TMEDA (2.50 mL, 16.5 mmol), sec-butyl lithium-hexane solution (0.99 mol/L, 16.6 mL, 16.5 mmol) and 1,2-dibromotetrachloroethane (2.92 g, 8.98 mmol), followed by purification by flash column chromatography (chloroform/methanol=95/5 to 90/10) to obtain 3-hydroxy-7-bromo-2-(1-methyl-1-phenylethyl)isoindolinone (2.20 g, yield 85%).

出典