反応 #4950

反応方程式

Dimethylamine

epichlorohydrin

methylamine

→

1-dimethylamino-3-methylamino-2-propanol hydrochloride

収率 84.0%

溶媒

methanol

反応条件

後処理

1. 1
   workup.STIRRINGStirring
2. 2
   その他for one hour
3. 3
   その他room temperature overnight
4. 4
   その他The solvents were evaporated

実験手順

Dimethylamine 22.6 g, 40% solution (0.2 mole) was added dropwise to a solution of 16 ml of epichlorohydrin (0.2 mole) in 100 ml of methanol at 5° C. stirring in an ice bath. After two hours at 5° C. a chilled solution of 86 ml methylamine of 40% solution (1 mole) was poured into the reaction mixture. Stirring was continued in ice bath for one hour and then room temperature overnight. The solvents were evaporated and the clear oil was pumped under vacuum at 75° C. for 1.5 hr to give 28.23 g (~84% yield) of 1-dimethylamino-3-methylamino-2-propanol hydrochloride (I) as the main product.

出典