反応 #49467

反応方程式

trimethylboroxine

potassium carbonate

7-amino-4-bromoisoindolinone

7-amino-4-methylisoindolinone

→

7-aminoisoindolinone

収率 96.5%

溶媒

water

dimethoxyethane

反応条件

後処理

1. 1
   その他followed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=4/1)
2. 2
   その他to obtain

実験手順

In a similar manner to Step 1 of Example 152, 7-amino-4-bromoisoindolinone (100 mg, 0.440 mmol) was dissolved in dimethoxyethane (5 mL), and the solution was treated with trimethylboroxine (0.184 mL, 1.76 mmol), [bis(diphenylphosphino)ferrocene]dichloropalladium (28.7 mg, 0.0352 mmol), potassium carbonate (304 mg, 2.20 mmol) and water (0.158 mL), followed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=4/1) to obtain a mixture of 7-amino-4-methylisoindolinone and 7-aminoisoindolinone (62.9 mg, ratio 10/1, yield 89%).

出典