反応 #49464

反応方程式

7-amino-4-bromoisoindolinone

vinyltributyltin

→

7-amino-4-vinylisoindolinone

収率 68.0%

溶媒

THF

反応条件

後処理

1. 1
   その他followed by purification by slurry

実験手順

In a similar manner to Step 1 of Example 10, 7-amino-4-bromoisoindolinone (300 mg, 1.32 mmol) was dissolved in THF (12 mL), and the solution was treated with vinyltributyltin (1.16 mL, 3.96 mmol) and bis(o-toluoylphosphine)dichloropalladium (166 mg, 0.211 mmol), followed by purification by slurry using hexane and chloroform to obtain 7-amino-4-vinylisoindolinone (155 mg, yield 68%).

出典