反応 #493944

反応方程式

water

2-fluoroethanol

triethylamine

(CF3SO2)2O

→

2-fluoroethyl trifluoromethanesulfonate

収率 82.0%

溶媒

dichloromethane

反応条件

後処理

1. 1
   洗浄The organic layer was washed with satd aq NaHCO3 (100 mL) and brine (100 mL)
2. 2
   その他dried
3. 3
   濃縮concentrated

実験手順

To a solution of 2-fluoroethanol (3.2 g, 50 mmol) and triethylamine (5.5 g, 55 mmol) in dichloromethane (60 mL) was added dropwise (CF3SO2)2O (15.5 g, 55 mmol) at −78° C. under N2. The mixture was stirred at 1020° C. for 1 h, and treated with water (100 mL). The organic layer was washed with satd aq NaHCO3 (100 mL) and brine (100 mL), dried, and concentrated to give 2-fluoroethyl trifluoromethanesulfonate (8 g, yield 82%).

出典