反応 #49381

反応方程式

triethylamine

4-chloro-7-iodoisoindolinone

→

Compound 156

収率 164.2%

4-Chloro-7-(1-methylindol-2-yl)isoindolinone

収率 164.2%

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他followed by purification by flash column chromatography (hexane/ethyl acetate=7/3, 3/2, 1/1)

実験手順

In a similar manner to Step 2 of Example 1, 4-chloro-7-iodoisoindolinone (84.0 mg, 0.286 mmol) was dissolved in acetonitrile (3 mL), and the solution was treated with Compound BK (100 mg, 0.571 mmol), palladium acetate (5.2 mg, 0.023 mmol) and triethylamine (0.400 mL, 2.87 mmol), followed by purification by flash column chromatography (hexane/ethyl acetate=7/3, 3/2, 1/1) to obtain Compound 156 (69.7 mg, yield 82%).

出典