反応 #49360

反応方程式

3-acetoxybenzoic acid

EDCI

HOBT monohydrate

cumylamine

→

3-acetoxy-N-(1-methyl-1-phenylethyl)benzamide

収率 73.1%

溶媒

DMF

反応条件

後処理

1. 1
   その他followed by purification by slurry

実験手順

In a similar manner to Step 1 of Example 137, 3-acetoxybenzoic acid (7.92 g, 44.0 mmol) was dissolved in DMF (45 mL), and the solution was treated with EDCI (12.7 g, 66.0 mmol), HOBT monohydrate (3.37 g, 22.0 mmol) and cumylamine (14.2 mL, 96.8 mmol), followed by purification by slurry using diisopropylether to obtain 3-acetoxy-N-(1-methyl-1-phenylethyl)benzamide (9.57 g, yield 73%).

出典