反応 #49355

反応方程式

4-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

trifluoroacetic acid

triethylsilane

→

4-methoxy-7-iodoisoindolinone

収率 78.0%

溶媒

nitromethane

反応条件

後処理

1. 1
   ろ過The obtained solid was collected by filtration
2. 2
   洗浄washed with ethyl acetate
3. 3
   その他The obtained solid was dried under reduced pressure

実験手順

In a similar manner to Step 4 of Example 16, 4-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (2.50 g, 5.91 mmol) was dissolved in nitromethane (100 mL), and the solution was treated with trifluoroacetic acid (4.50 mL, 59.1 mmol) and triethylsilane (1.90 mL, 11.8 mmol). The obtained solid was collected by filtration and washed with ethyl acetate. The obtained solid was dried under reduced pressure to obtain 4-methoxy-7-iodoisoindolinone (1.32 g, yield 78%).

出典