反応 #49318
ord-4e1bcd5b259347909719a0d0734128f4
反応方程式
4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone
2-(2-aminoethoxy)ethanol
sodium triacetoxyborohydride
→
4-chloro-7-{1-(tert-butoxycarbonyl)-5-[2-(2-hydroxyethoxy)ethylaminomethyl]indol-2-yl}isoindolinone
反応物
試薬
なし
反応条件
詳細条件
See reaction.notes.procedure_details.
実験手順
In a similar manner to Step 1 of Example 56, 4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (20.0 mg, 0.0487 mmol) was dissolved in dichloromethane (0.5 mL). The solution was treated with 2-(2-aminoethoxy)ethanol (0.010 mL, 0.10 mmol) and sodium triacetoxyborohydride (48 mg, 0.23 mmol) to obtain 4-chloro-7-{1-(tert-butoxycarbonyl)-5-[2-(2-hydroxyethoxy)ethylaminomethyl]indol-2-yl}isoindolinone.