反応 #49263

反応方程式

1-(tert-Butoxycarbonyl)-4-piperidinone

hydrogen chloride methanol

diisopropyl ether

→

4,4-dimethoxypiperidine hydrochloride

収率 65.0%

溶媒

methanol

反応条件

後処理

1. 1
   ろ過the precipitated solid was collected by filtration
2. 2
   洗浄washed with diisopropyl ether
3. 3
   その他dried under reduced pressure

実験手順

1-(tert-Butoxycarbonyl)-4-piperidinone (400 mg, 2.01 mmol) was dissolved in methanol (4 mL), and the solution was added with 10% hydrogen chloride-methanol solution (4 mL), followed by stirring at 50° C. for 2 hours. The reaction mixture was added with diisopropyl ether and the precipitated solid was collected by filtration, washed with diisopropyl ether and then dried under reduced pressure to obtain 4,4-dimethoxypiperidine hydrochloride (238 mg, yield 65%).

出典