反応 #492367

反応方程式

2-bromo-4,6-bis(trifluoromethyl)benzaldehyde

ethyl 3-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamido)propanoate

K2CO3

→

title compound

ethyl 3-(5-(2-formyl-3,5-bis(trifluoromethyl)phenyl)picolinamido)propanoate

溶媒

1,4-dioxane

DCM

反応条件

後処理

1. 1
   温度After 70 min the resulting mixture was cooled to room temperature
2. 2
   乾燥dried (Na2SO4)
3. 3
   濃縮concentrated
4. 4
   その他purified via column chromatography

実験手順

2-bromo-4,6-bis(trifluoromethyl)benzaldehyde (100 mg, 0.31 mmol), ethyl 3-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamido)propanoate (119 mg, 0.34 mmol), Pd(dppf)Cl2 (23 mg, 0.03 mmol), and 2M K2CO3 (0.31 mL, 0.62 mmol), were dissolved in 1,4-dioxane (1.0 mL) and heated to 100° C. After 70 min the resulting mixture was cooled to room temperature, diluted with DCM, dried (Na2SO4), concentrated and purified via column chromatography to yield the title compound.

出典