反応 #492364

反応方程式

2-chloro-6-methylbenzaldehyde

ethyl 3-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamido)propanoate

K3PO4

→

title compound

ethyl 3-(5-(2-formyl-3-methylphenyl)picolinamido)propanoate

溶媒

1,4-dioxane

DCM

反応条件

後処理

1. 1
   温度After 4 h the resulting mixture was cooled to room temperature
2. 2
   乾燥dried (Na2SO4)
3. 3
   濃縮concentrated
4. 4
   その他purified via column chromatography

実験手順

2-chloro-6-methylbenzaldehyde (156 mg, 1.01 mmol), ethyl 3-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamido)propanoate (434 mg, 1.25 mmol), Pd(PPh3)4 (58 mg, 0.05 mmol), and 2M K3PO4 (aq) (1.0 mL, 2.00 mmol) were dissolved in 1,4-dioxane (3.0 mL) and heated to 100° C. After 4 h the resulting mixture was cooled to room temperature, diluted with DCM, dried (Na2SO4), concentrated and purified via column chromatography to yield the title compound.

出典