反応 #49218

反応方程式

3-(methoxycarbonyl)benzoic acid

HATU

dipropylamine

( 1 )

(2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

Methyl 3-(dipropylcarbamoyl)benzoate

→

title compound

3-(dipropylcarbamoyl)benzoic acid

溶媒

DMF

Ethyl acetate

反応条件

後処理

1. 1
   洗浄the mixture was washed with H2O
2. 2
   その他dried
3. 3
   濃縮concentrated

実験手順

Step E (1): Methyl 3-(dipropylcarbamoyl)benzoate. To a solution of 3-(methoxycarbonyl)benzoic acid (6.7 g, 37.2 mmol) in DMF (60 mL) was added HATU (17.0 g, 44.7 mmol) and dipropylamine (9.4 g, 93 mmol) and the reaction mixture was stirred at rt overnight. Ethyl acetate (600 mL) was added and the mixture was washed with H2O, dried and concentrated to give the title compound was used in the next step without purification.

出典