反応 #491653

反応方程式

8-oxa-3-azabicyclo[3.2.1]octane hydrochloride

1-(4,6-dichloro-1,3,5-triazin-2-yl)piperidin-4-one

sodium carbonate

→

1-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-chloro-1,3,5-triazin-2-yl)piperidin-4-one

溶媒

acetone

反応条件

後処理

1. 1
   温度to cool to room temperature
2. 2
   ろ過The title compound was collected by filtration
3. 3
   洗浄washed with water
4. 4
   その他dried under vacuum

実験手順

To an aqueous solution of 8-oxa-3-azabicyclo[3.2.1]octane hydrochloride (66 mL) was added 1-(4,6-dichloro-1,3,5-triazin-2-yl)piperidin-4-one (2.7 g, 11 mmol) as a suspension in acetone (40 mL). To the mixture was added solid sodium carbonate (2.5 g, 24 mmol). The suspension was stirred at 80° C. for two hours and then allowed to cool to room temperature. The title compound was collected by filtration, washed with water, and dried under vacuum; MS (ES+) 324.4 (M+H)+

出典