反応 #491648

反応方程式

8-oxa-3-azabicyclo[3.2.1]octane hydrochloride

tert-butyl 4-(4,6-dichloro-1,3,5-triazin-2-yl)piperazine-1-carboxylate

sodium carbonate

→

tert-butyl 4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-chloro-1,3,5-triazin-2-yl)piperazine-1-carboxylate

溶媒

water

acetone

反応条件

後処理

1. 1
   workup.ADDITIONwas added in a single portion
2. 2
   温度to cool to room temperature
3. 3
   その他the title compound was removed by filtration
4. 4
   洗浄washed with water
5. 5
   その他dried under vacuum

実験手順

To a solution of 8-oxa-3-azabicyclo[3.2.1]octane hydrochloride (0.49 g, 3.3 mmol) in water (18 mL) was added a suspension of tert-butyl 4-(4,6-dichloro-1,3,5-triazin-2-yl)piperazine-1-carboxylate (1.0 g, 3.0 mmol) in acetone (about 10 mL). The suspension was stirred magnetically while solid sodium carbonate (0.70 g, 6.6 mmol) was added in a single portion. The mixture was stirred for two hours while heating in a 70-75° C. in an oil bath. After allowing the mixture to cool to room temperature, the title compound was removed by filtration, washed with water, and dried under vacuum.

出典