反応 #49113

反応方程式

2-(methyloxy)-4,6-bis(trifluoromethyl)benzoic acid

oxalyl chloride

→

title product

収率 109.3%

2-(Methyloxy)-4,6-bis(trifluoromethyl)benzoyl chloride

収率 109.3%

溶媒

DCM

反応条件

後処理

1. 1
   その他to reach room temperature
2. 2
   その他was evaporated in vacuo

実験手順

To a solution of 2-(methyloxy)-4,6-bis(trifluoromethyl)benzoic acid (20.2 g; 70.14 mmol) in dry DCM (400 mL), at 0° C., was added dropwise oxalyl chloride (13.4 mL; 154.31 mmol) followed by dry DMF (5 drops). The reaction was allowed to reach room temperature. After overnight stirring the solvent was evaporated in vacuo to get the title product (23.5 g) as a yellow slurry used without further purification.

出典