反応 #49097

反応方程式

phenyllithium

sodium borohydride

(±)-1-(2-methyl-1-pyrrolidinyl)cyclopentanecarbonitrile

methanol

→

ammonia

title compound

収率 46.0%

(±)-[[1-(2-methyl-1-pyrrolidinyl)cyclopentyl](phenyl)methyl]amine

収率 46.0%

溶媒

THF

反応条件

後処理

1. 1
   その他Reaction
2. 2
   温度cooled to 0° C.
3. 3
   その他to react at 20° C. overnight
4. 4
   温度The reaction was cooled to 0° C.
5. 5
   その他quenched with saturated sodium bicarbonate
6. 6
   抽出extracted with ethyl acetate
7. 7
   乾燥dried (Na2SO4)
8. 8
   その他evaporated
9. 9
   その他The product was purified by chromatography on a 5 g SCX column
10. 10
    洗浄eluting from 0-100% ethyl acetate in pet. ether, 0-10% methanol in ethyl acetate

実験手順

A solution of (±)-1-(2-methyl-1-pyrrolidinyl)cyclopentanecarbonitrile D39 (0.997 g; 5.6 mmol) in dry THF was cooled to −70° C. To this phenyllithium (1.7M in C6H14/ether, 1.1 equiv) was added slowly. The whole mixture was allowed to warm slowly to room temperature over 3 h with stirring under argon. Reaction cooled to 0° C. and methanol added followed by sodium borohydride (portionwise) and allowed to react at 20° C. overnight. The reaction was cooled to 0° C. and quenched with saturated sodium bicarbonate, extracted with ethyl acetate, dried (Na2SO4) and evaporated. The product was purified by chromatography on a 5 g SCX column eluting from 0-100% ethyl acetate in pet. ether, 0-10% methanol in ethyl acetate then 2% 0.880 ammonia in ethyl acetate to give the title compound as an oil (0.67 g; 46%) was obtained. Mass Spectrum (Electrospray LC/MS): Found 259 (MH+). C17H26N2 requires 258. Ret. time 1.19 min.

出典