反応 #49040

反応方程式

3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionic acid methyl ester

methylamine

→

title compound

3-aminooxy-2,2,N-trimethyl-propionamide

溶媒

methanol

反応条件

後処理

1. 1
   濃縮After the reaction mixture was concentrated under reduced pressure, dichloromethane
2. 2
   workup.ADDITIONwas added to the residue, and insoluble matter
3. 3
   ろ過was filtered
4. 4
   濃縮The filtrate was concentrated
5. 5
   その他the residue was purified by silica gel column chromatography

実験手順

To 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionic acid methyl ester (800 mg) obtained in Step A was added a 40% solution of methylamine in methanol (6 ml), and the mixture was stirred at 60° C. for 13 hours. After the reaction mixture was concentrated under reduced pressure, dichloromethane was added to the residue, and insoluble matter was filtered. The filtrate was concentrated, and the residue was purified by silica gel column chromatography to give the title compound (202 mg).

出典