反応 #49034

反応方程式

formyl-N-(2-hydroxy-ethoxy)-benzamide

3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-formyl-N-(2-hydroxy-ethoxy)-benzamide

2-methyl-propane-1,2-diol

→

title compound

3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-(2-hydroxy-1,1-dimethyl-ethoxymethyl)-N-(2-hydroxy-ethoxy)-benzamide

反応条件

後処理

1. 1
   その他used as a reagent in Step G of Example 1, synthesis similar to that in Step G of Example 1

実験手順

Using 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5, formyl-N-(2-hydroxy-ethoxy)-benzamide obtained in Step F of Example 1 as a starting material, and 2-methyl-propane-1,2-diol obtained in Step A instead of ethylene glycol used as a reagent in Step G of Example 1, synthesis similar to that in Step G of Example 1 was performed. The resultant cyclic acetal was subjected to reduction condition similar to that in Step H of Example 1 to give the title compound.

出典