反応 #49023

反応方程式

isopropylamine

3-(1-ethoxy-ethylideneaminooxy)-propanoic acid methyl ester

isopropylamine

→

N-(2-isopropylcarbamoyl-ethoxy)-acetimidic acid ethyl ester

収率 13.0%

溶媒

methanol

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture was stirred for 3 hours
2. 2
   その他a focused microwave synthesis system (Discover™, CEM) at 100 W
3. 3
   濃縮The reaction mixture was concentrated under reduced pressure
4. 4
   その他the residue was purified by silica gel column chromatography

実験手順

To a known compound, 3-(1-ethoxy-ethylideneaminooxy)-propanoic acid methyl ester (CAS No. 97164-30-2, 300 mg, 1.585 mmol) were added methanol (3 ml) and isopropylamine (1.4 ml), and the mixture was stirred at 55° C. for 14 hours. Additional isopropylamine (1.0 ml) was added, and the mixture was stirred for 3 hours using a focused microwave synthesis system (Discover™, CEM) at 100 W. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to give N-(2-isopropylcarbamoyl-ethoxy)-acetimidic acid ethyl ester (46 mg, 13% yield).

出典