反応 #48938

反応方程式

ethyl 4-bromobutanoate

4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one

→

title compound

Ethyl 4-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2H-chromen-8-yloxy)butanoate

反応条件

実験手順

The title compound was prepared from ethyl 4-bromobutanoate and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedure outlined in Example 25. 1H NMR (400 MHz, DMSO-d6): δ 9.51 (s, 1H), 8.81 (s, 2H), 7.95 (d, 1H), 7.20 (d, 1H), 4.64 (s, 1H), 4.10-3.95 (m, 4H), 3.91 (s, 3H), 2.54 (t, 2H), 1.90 (m, 2H), 1.16 (t, 3H); MS (ESI): 466.9.

出典