反応 #48908

反応方程式

8-(cyclopentyloxy)-4-hydroxy-7-methoxy-2H-chromen-2-one

ammonium acetate

→

4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one

溶媒

m-xylene

反応条件

後処理

1. 1
   温度was refluxed under N2
2. 2
   濃縮the reaction was concentrated
3. 3
   その他purified by silica gel chromatography (3:2→0:1; hexanes:ethyl acetate)

実験手順

A mixture of 8-(cyclopentyloxy)-4-hydroxy-7-methoxy-2H-chromen-2-one (450 mg, 1.63 mmol, Example 1, Step 2), ammonium acetate (3.0 g, 39 mmol), and anhydrous m-xylene (8 mL) was refluxed under N2. After 3 h, the reaction was concentrated and purified by silica gel chromatography (3:2→0:1; hexanes:ethyl acetate) to give 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one: MS (ESI): 275.9.

出典